His first act was to receive many refugees such as the Samians and other Ionian fugitives who had left Greece because of the Persian wars. He then moved on to something he was passionate about: dominating the Strait. He ordered the construction of the beautiful fortress of Scilla for peace of mind and to remind all that he occupied the area. He then reinforced and strengthened his fleet, waiting for the perfect time to attack “Zancle” the ancient name of Messina. Anassila was eager to form a colony in Sicily, and with Zancle there ready and waiting to be occupied, he could not resist. He encouraged the Samians to seize Zancle, and a plan was hatched. The Zanclei learnt of his plans to conquer their city and asked for help from a very influential figure in those days in Sicily, the tyrant Hippocrates of Gela. He was reluctant however to be involved in a war against Anassila as he and his Reggio had become very powerful and eventually joined and allied with him against Zancle.
Once Zancle was conquered, Anassila besieged the city himself and took power from the Samians. He renamed the city to Messana, after his native Messene (a region in the Pelopennese). With the Samians no longer in power and betrayed, it was not long before another betrayal was afoot. Gela, with the crucial support of Syracuse, attacked Himera, where the tyrant Terillo (father in law of Anassila) was forced to flee. He obtained the assistance of the Carthaginians for his father-in-law, who had been expelled from his city by Theron, tyrant of Agrigentum. Anassila was in trouble. Syracuse was ever expanding and such he had had to give up on his military campaign and ideas of war against Locri (city historically allied with Syracuse). He came to a realisation and to not lose it all, put aside his warlike intentions and married the daughter of Gelo. All seemed well, and after saving Reggio and achieving most of his goals, he died. He left a valuable political legacy as well as being without doubt one of the most interesting conquerers in the history of Reggio Calabria.